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Selected Publications

> TransCon Growth Hormone
> TransCon PTH
> TransCon CNP
> Archived Publications

TransCon Growth Hormone

User Driven Development of a New Device for Weekly Growth Hormone Administration in Pediatric Patients
K.Sprogøe, S. Jensen, H. Egesborg, P.E. Fabricius, B. Sørensen, and S.V. Jacobsen, Ascendis Pharma A/S, Medicom Innovation Partner. Poster presented at the 10th International Meeting of Pediatric Endocrinology (IMPE), September 14-17, 2017 (Washington, D.C.)

Development of a Long-Acting Growth Hormone (LAGH): Size Matters
P. Saenger, D.B. Karpf, E. Mortensen, M. Beckert, K. Sprogøe, J. Leff, Albert Einstein College of Medicine, Ascendis Pharma, Inc., Ascendis Pharma, A/S. Poster presented at the 10th International Meeting of Pediatric Endocrinology (IMPE), September 14-17, 2017 (Washington, D.C.)

Design and Clinical Development of TransCon Growth Hormone for Growth Hormone Deficiency
M.Beckert, J.M. Mikkelsen, G.N. Rasmussen, H. Rau, K. Sprogoe, J.A. Leff. Poster presented at The Endocrine Society (ENDO) Annual Meeting and Expo, April 1-4, 2017 (Orlando, FL).

User Driven Development of a New Device for Weekly Growth Hormone Administration in Pediatric Patients
S. Jensen, H. Egesborg, P.E. Fabricius, B. Sørensen, S.V. Jacobsen. Poster presented at The Endocrine Society (ENDO) Annual Meeting and Expo, April 1-4, 2017 (Orlando, FL).

Design of a Bracketed Dosing Regimen for the Administration of TransCon GH, a Once-Weekly Growth Hormone Product
K. Sprogoe, S. Jensen, H. Egesborg. Poster presented at The Endocrine Society (ENDO) Annual Meeting and Expo, April 1-4, 2017 (Orlando, FL).

Design and Rationale for the Height Trial, a Phase 3 TransCon GH Study in Children with Growth Hormone Deficiency
M. Beckert, D.B. Karpf, E. Mortensen, J. Mardell, E.D. Christoffersen, J.A. Leff. Poster presented at The Endocrine Society (ENDO) Annual Meeting and Expo, April 1-4, 2017 (Orlando, FL).

A Randomized Phase 2 Study of Long-Acting TransCon Growth Hormone vs. Daily GH in Childhood GH Deficiency
P. Chatelain, O. Malievsky, K. Radziuk, G. Senatorova, M. Abdou, E. Vlachopapadopolou, Y. Skorodok, V. Peterkova, J. Leff, M. Beckert, the TransCon GH Working Group. JCEM. 2017. jc.2016-3776. doi: 10.1210/jc.2016-3776.

A Phase 2 Trial of Long-acting TransCon Growth Hormone in Adult GH Deficiency
C. Höybye, A. Pfeiffer, D. Ferone, J. Christiansen, D. Gilfoyle, E. Christoffersen, E. Mortensen, J. Leff and M. Beckert. Endocr Connect. 2017. EC-17-0007.

TransCon PTH

TransCon PTH, a Sustained-Release PTH Prodrug for the Treatment of Hypoparathyroidism: Proof-of-Principle in Cynomolgus Monkeys and TPTx Rats
L. Holten-Andersen, M. Guillot, F. Cleemann, M. Felx, S. Pihl, K. Sprogøe, D. Karpf, A. Valera, V.M. Breinholt, Ascendis Pharma; Charles River Laboratories. Poster presented at the American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting, September 8-11 (Denver, CO).

Pharmacokinetics of TransCon PTH, a Sustained-Release PTH Prodrug for Hypoparathyroidism, in Rat and Cynomolgus Monkey
S. Pihl, M. Krusch, L. Holten-Andersen, J. Zettler, F.Cleemann, C.E. Rasmussen, K. Sprogoe, D. Karpf, V.M. Breinholt, Ascendis Pharma. Poster presented at the American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting, September 8-11 (Denver, CO).

TransCon PTH, a Sustained Release PTH Analogue for the Treatment of Hypoparathyroidism – Proof-of-Principle in Monkeys and Tptx Rats
K.Sprogoe, L. Holten-Andersen, F. Cleeman, J. Zettler, S. Pihl, V.M. Breinholt. Poster presented at The Endocrine Society (ENDO) Annual Meeting and Expo, April 1-4, 2017 (Orlando, FL).

Pharmacokinetics of TransCon PTH, a Sustained-Release PTH Prodrug for Hypoparathyroidism, in Rat and Cynomolgus Monkey
K. Sprogoe, S. Pihl, C.E. Rasmussen, L. Holten-Andersen, F. Cleeman, V.M. Breinholt. Poster presented at The Endocrine Society (ENDO) Annual Meeting and Expo, April 1-4, 2017 (Orlando, FL).

TransCon CNP

TransCon CNP, a Sustained-Release Prodrug of C-type Natriuretic Peptide, Prevents Premature Synchondroses Closure in an Achondroplasia Mouse Model
V.M. Breinholt, M. Cornille, N. Kaci, L. Legeai-Mallet, Ascendis Pharma A/S, Imagine Institute. Poster presented at the American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting, September 8-11 (Denver, CO).

Pharmacokinetics and Cardiovascular Assessment of TransCon CNP, a Sustained-Release C-type Natriuretic Peptide Prodrug, for the Treatment of Achondroplasia
C.E. Rasmussen, K. Sprogøe, U. Hersel, T. Wegge, F. Faltinger, P. Mygind, and V.M. Breinholt, Ascendis
Pharma. Poster presented at the American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting, September 8-11 (Denver, CO).

TransCon CNP, a Sustained-Release Prodrug of C-Type Natriuretic Peptide, exerts Positive Effects on Bone in Juvenile Cynomolgus Monkeys and in a Mouse Model of Achondroplasia
V.M. Breinholt, N. Kaci, C.E. Rasmussen, O. Keil, S. Adermann, U. Hersel, M. Cornille, M. Guillot, N. Doyle, A. Valera; P. Mygind, K. Sprogøe, L. Legeai-Mallet, Ascendis Pharma A/S; Ascendis Pharma GmbH, and Imagine Institute, Charles River Laboratories. Poster presented at the American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting, September 8-11 (Denver, CO).

TransCon CNP, a Sustained-Release Prodrug of C-Type Natriuretic Peptide, Effects Positive Bone Growth in Young Cynomolgus Monkeys and in a Mouse Model of Achondroplasia
V.M. Breinholt, N.Kaci, C.E. Rasmussen, O. Keil, S. Adermann, U. Hersel, M. Cornille, P. H. Mygind, K. Sprogoe, L. Legeai-Mallet. Poster presented at The Endocrine Society (ENDO) Annual Meeting and Expo, April 1-4, 2017 (Orlando, FL).

TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Analogue, for the Treatment of Achondroplasia
K. Sprogoe, C.E. Rasmussen, U. Hersel, V.M. Breinholt. Poster presented at The Endocrine Society (ENDO) Annual Meeting and Expo, April 1-4, 2017 (Orlando, FL).

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